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ID: ALA1151857
Journal: Bioorg Med Chem Lett
Title: A new psoralen derivative with enlarged antiproliferative properties.
Authors: Dalla Via L, González-Gómez JC, Pérez-Montoto LG, Santana L, Uriarte E, Marciani Magno S, Gia O.
Abstract: Following our results with benzopsoralens as potent photochemotherapeutic agents, we report the antiproliferative evaluation of nitrogenated isoster upon and without UVA irradiation. The evaluated pyridazinopsoralen showed a higher photochemotherapeutic activity with respect to the well-known drug, 8-MOP, and a significant cytotoxicity, also in the dark. This result enlarges the interest in this tetracyclic psoralen derivative skeleton in the search of new anticancer agents.
CiteXplore: 19359172