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ID: ALA1151865
Journal: Bioorg Med Chem Lett
Title: New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
Authors: Regnier T, Sarma D, Hidaka K, Bacha U, Freire E, Hayashi Y, Kiso Y.
Abstract: A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds.
CiteXplore: 19362479