Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.

ID: ALA1151869

Journal: Bioorg Med Chem Lett

Title: Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.

Authors: Mitsuya M, Kamata K, Bamba M, Watanabe H, Sasaki Y, Sasaki K, Ohyama S, Hosaka H, Nagata Y, Eiki J, Nishimura T.

Abstract: A novel class of 3,6-disubstituted 2-pyridinecarboxamide derivatives was designed based on X-ray analysis of the 2-aminobenzamide lead class. Subsequent chemical modification led to the discovery of potent GK activators which eliminate potential toxicity concerns associated with an aniline group of the lead structure. Compound 7 demonstrated glucose lowering effect in a rat OGTT model.

CiteXplore: 19362831

DOI: 10.1016/j.bmcl.2009.03.137

Patent ID: ┄