Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.

ID: ALA1151885

Journal: Bioorg Med Chem Lett

Title: Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation.

Authors: Ralbovsky JL, Lisko JG, Palmer JM, Mabus J, Chevalier KM, Schulz MJ, Dyatkin AB, Miskowski TA, Coats SJ, Hornby P, He W.

Abstract: A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue.

CiteXplore: 19375913

DOI: 10.1016/j.bmcl.2009.03.157

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