Cyclic glycopeptidomimetics through a versatile sugar-based scaffold.
Basic Information
ID: ALA1151907
Journal: Bioorg Med Chem Lett
Title: Cyclic glycopeptidomimetics through a versatile sugar-based scaffold.
Authors: Altamura M, Dragoni E, Infantino AS, Legnani L, Ludbrook SB, Menchi G, Toma L, Nativi C.
Abstract: Cyclic peptidomimetics are attracting structures to obtain a distinct, bioactive conformation. Even more attractive are sugar-containing cyclic peptidomimetics which present turn structures induced by the pyranose ring when incorporated in cyclic peptides. The use of a new and versatile saccharidic scaffold to achieve sugar-based peptidomimetics is here reported together with the successful synthesis of diastereomerically pure cyclic SAA peptidomimetics 15 and 16.
CiteXplore: 19395262
DOI: 10.1016/j.bmcl.2009.04.008
Patent ID: ┄