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ID: ALA1151915
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Authors: Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C.
Abstract: Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.
CiteXplore: 19410457