Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.

ID: ALA1152187

Journal: Bioorg Med Chem Lett

Title: Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.

Authors: Kojima N, Hayashi H, Suzuki S, Tominaga H, Maezaki N, Tanaka T, Yamori T.

Abstract: C4-Fluorinated analogues of solamin, an antitumor acetogenin, were synthesized and investigated for their antitumor activities against 39 tumor cell lines. C4-Fluorinated solamins showed more potent growth inhibitory activity against cancer cell lines than solamin.

CiteXplore: 18993063

DOI: 10.1016/j.bmcl.2008.10.069

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