Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents.

ID: ALA1152210

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents.

Authors: Takaishi K, Izumi M, Baba N, Kawazu K, Nakajima S.

Abstract: We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

CiteXplore: 18793855

DOI: 10.1016/j.bmcl.2008.08.102

Patent ID: ┄