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ID: ALA1152225
Journal: Bioorg Med Chem Lett
Title: Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Authors: Pescatore G, Kinzel O, Attenni B, Cecchetti O, Fiore F, Fonsi M, Rowley M, Schultz-Fademrecht C, Serafini S, Steinkühler C, Jones P.
Abstract: Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading to potent and selective class I HDAC inhibitors with good dog PK.
CiteXplore: 18809328