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ID: ALA1152231
Journal: Bioorg Med Chem Lett
Title: Discovery of small molecule agonists for the bombesin receptor subtype 3 (BRS-3) based on an omeprazole lead.
Authors: Carlton DL, Collin-Smith LJ, Daniels AJ, Deaton DN, Goetz AS, Laudeman CP, Littleton TR, Musso DL, Morgan RJ, Szewczyk JR, Zhang C.
Abstract: Starting from a weak omeprazole screening hit, replacement of the pyridine with a 1,3-benzodioxole moiety, modification of the thioether linkage, and substitution of the benzimidazole pharmacophore led to the discovery of nanomolar BRS-3 agonists.
CiteXplore: 18818070