Document Report Card

ID: ALA1152273

Journal: J Med Chem

Title: Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors.

Authors: Ramurthy S, Subramanian S, Aikawa M, Amiri P, Costales A, Dove J, Fong S, Jansen JM, Levine B, Ma S, McBride CM, Michaelian J, Pick T, Poon DJ, Girish S, Shafer CM, Stuart D, Sung L, Renhowe PA.

Abstract: A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

CiteXplore: 18942827

DOI: 10.1021/jm801050k