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ID: ALA1152283

Journal: Bioorg Med Chem Lett

Title: Design at the atomic level: generation of novel hybrid biaryloxazolidinones as promising new antibiotics.

Authors: Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, Johnson G.

Abstract: From the X-ray crystal structures of linezolid and the non-selective antibiotic sparsomycin, we have derived a new family of hybrid oxazolidinones. From this initial compound set we have developed a new biaryloxazolidinone scaffold that shows both potent antimicrobial activity as well as selective inhibition of ribosomal translation. The synthesis of these compounds is outlined.

CiteXplore: 18951792

DOI: 10.1016/j.bmcl.2008.10.014