Document Report Card

ID: ALA1152310

Journal: J Nat Prod

Title: A Dimeric sesquiterpenoid from a Malaysian Meiogyne as a new inhibitor of Bcl-xL/BakBH3 domain peptide interaction.

Authors: Litaudon M, Bousserouel H, Awang K, Nosjean O, Martin MT, Dau ME, Hadi HA, Boutin JA, Sévenet T, Guéritte F.

Abstract: In an effort to find potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on 1470 Malaysian plant extracts. The ethyl acetate extract obtained from the bark of Meiogyne cylindrocarpa was selected for its interaction with the Bcl-xL/Bak association. Bioassay-guided purification of this species led to the isolation of two new dimeric sesquiterpenoids (1 and 2) possessing an unprecedented substituted cis-decalin carbon skeleton. Meiogynin A (1) showed the strongest activity with a K(i) of 10.8 +/- 3.1 microM.

CiteXplore: 19161318

DOI: 10.1021/np8006292