Document Report Card

ID: ALA1152312

Journal: J Nat Prod

Title: Neopyrrolomycins with broad spectrum antibacterial activity.

Authors: Hopp DC, Rhea J, Jacobsen D, Romari K, Smith C, Rabenstein J, Irigoyen M, Clarke M, Francis L, Luche M, Carr GJ, Mocek U.

Abstract: Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).

CiteXplore: 19191549

DOI: 10.1021/np800632f