Document Report Card

ID: ALA1152322

Journal: J Nat Prod

Title: Evaluating indole-related derivatives as precursors in the directed biosynthesis of diazepinomicin analogues.

Authors: Ratnayake AS, Janso JE, Feng X, Schlingmann G, Goljer I, Carter GT.

Abstract: The effectiveness of precursor-directed biosynthesis to generate diazepinomicin (1) analogues with varied ring-A substitutents was investigated by feeding commercially available, potential ring-A precursors such as fluorinated tryptophans, halogenated anthranilates, and various substituted indoles into growing actinomycete culture DPJ15 (genus Micromonospora). Two new monofluorinated diazepinomicin analogues (2 and 3) were identified and characterized by spectroscopic methods. Both derivatives showed modest antibacterial activity against the Gram-positive coccus Staphylococcus aureus with MIC values in the range 8-32 microg/mL.

CiteXplore: 19199816

DOI: 10.1021/np800664u