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ID: ALA1152365

Journal: Bioorg Med Chem Lett

Title: First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

Authors: Palmioli A, Sacco E, Abraham S, Thomas CJ, Di Domizio A, De Gioia L, Gaponenko V, Vanoni M, Peri F.

Abstract: By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a (15)N-edited HSQC NMR experiment the ligand-Ras binding interface.

CiteXplore: 19515561

DOI: 10.1016/j.bmcl.2009.05.107