Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.

ID: ALA1152393

Journal: Bioorg Med Chem Lett

Title: Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.

Authors: Micheli F, Holmes I, Arista L, Bonanomi G, Braggio S, Cardullo F, Di Fabio R, Donati D, Gentile G, Hamprecht D, Terreni S, Heidbreder C, Savoia C, Griffante C, Worby A.

Abstract: The lead optimization process to identify new selective dopamine D(3) receptor antagonists is reported. DMPK parameters and binding data suggest that selective D(3) receptor antagonists as potential PET ligands might have been identified.

CiteXplore: 19553113

DOI: 10.1016/j.bmcl.2009.06.028

Patent ID: ┄