The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.

ID: ALA1152417

Journal: Bioorg Med Chem Lett

Title: The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.

Authors: Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto L, Emmons A, Holmes IP, Montanari D, Norris R, Walters DJ, Watson SP.

Abstract: A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.

CiteXplore: 19581086

DOI: 10.1016/j.bmcl.2009.06.035

Patent ID: ┄