Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
Basic Information
ID: ALA1152527
Journal: Bioorg Med Chem
Title: Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
Authors: León LG, Donadel OJ, Tonn CE, Padrón JM.
Abstract: A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
CiteXplore: 19664930
DOI: 10.1016/j.bmc.2009.07.053
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