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ID: ALA1152560
Journal: Bioorg Med Chem
Title: Substituted 2-arylbenzothiazoles as kinase inhibitors: hit-to-lead optimization.
Authors: Tasler S, Müller O, Wieber T, Herz T, Pegoraro S, Saeb W, Lang M, Krauss R, Totzke F, Zirrgiebel U, Ehlert JE, Kubbutat MH, Schächtele C.
Abstract: Based on an (aminoaryl)benzothiazole quinazoline hit structure for kinase inhibition, a systematic optimization program resulted in a lead structure allowing for inhibitory activities in cellular phosphorylation assays in the low nanomolar range.
CiteXplore: 19692247