Document Report Card
Basic Information
ID: ALA1152570
Journal: Bioorg Med Chem
Title: Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.
Authors: Asada M, Obitsu T, Nagase T, Sugimoto I, Yamaura Y, Sato K, Narita M, Ohuchida S, Nakai H, Toda M.
Abstract: A series of acrylic acids and their structurally related compounds were evaluated for their binding affinity to four EP receptor subtypes (EP1-4). Starting from the initial hit 3, which was discovered in our in-house library, compounds 4 and 5 were identified as new chemical leads as candidates for further optimization towards a selective EP3 receptor antagonist. The identification process of these compounds and their pharmacokinetic profiles are presented.
CiteXplore: 19700331