The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors.
Basic Information
ID: ALA1152690
Journal: Bioorg Med Chem
Title: The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors.
Authors: Pearson MS, Floquet N, Bello C, Vogel P, Plantier-Royon R, Szymoniak J, Bertus P, Behr JB.
Abstract: Nitrogen-in-the-ring analogues of l-fucose and l-rhamnose were prepared, which feature a spirocyclopropyl moiety in place of the methyl group of the natural sugar. The synthetic route involved a titanium-mediated aminocyclopropanation of a glycononitrile as the key step. Four new spirocyclopropyl iminosugar analogues were generated, which displayed some activity towards l-fucosidase and l-rhamnosidase.
CiteXplore: 19875298
DOI: 10.1016/j.bmc.2009.10.010
Patent ID: ┄
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