Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

ID: ALA1152724

Journal: Bioorg Med Chem

Title: Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2.

Authors: Najda-Bernatowicz A, Łebska M, Orzeszko A, Kopańska K, Krzywińska E, Muszyńska G, Bretner M.

Abstract: New derivatives of 4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole (TBBt), 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi), and N-substituted tetrabromophthalimides were synthesized and their effect on the activity of human protein kinase CK2 was examined. The most active were derivatives with N-hydroxypropyl substituents (IC(50) in 0.32-0.54 microM range) whereas derivatives of phthalimide were almost ineffective.

CiteXplore: 19168362

DOI: 10.1016/j.bmc.2008.12.071

Patent ID: ┄