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ID: ALA1152728

Journal: Bioorg Med Chem Lett

Title: 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.

Authors: Barber CG, Blakemore DC, Chiva JY, Eastwood RL, Middleton DS, Paradowski KA.

Abstract: The development of a new class of CCR5 antagonist replacing the tropane core of maraviroc by piperidine with a branched N-substituent is described. Compound 15h shows good whole cell antiviral activity together with microsomal stability and only weak activity at the hERG ion channel.

CiteXplore: 19171484

DOI: 10.1016/j.bmcl.2009.01.009