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ID: ALA1152740

Journal: Bioorg Med Chem

Title: Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones.

Authors: Laube T, Bernet A, Dahse HM, Jacobsen ID, Seifert K.

Abstract: Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity.

CiteXplore: 19188072

DOI: 10.1016/j.bmc.2009.01.028