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ID: ALA1152883

Journal: Bioorg Med Chem Lett

Title: 1-Amido-1-phenyl-3-piperidinylbutanes--CCR5 antagonists for the treatment of HIV: part 2.

Authors: Barber CG, Blakemore DC, Chiva JY, Eastwood RL, Middleton DS, Paradowski KA.

Abstract: Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.

CiteXplore: 19185490

DOI: 10.1016/j.bmcl.2009.01.008