Document Report Card

Basic Information

ID: ALA1152905

Journal: Bioorg Med Chem Lett

Title: Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

Authors: Ito M, Sakamoto T, Suzuki T, Egashira S, Moriya M, Ishihara A, Iwaasa H, Matsushita H, Nakase K, Wallace MA, Dean D, Sato N, Tokita S, Kanatani A.

Abstract: We have developed and characterized [(35)S]4a as a potent and selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R). Compound [(35)S]4a showed appreciable specific signals in brain slices prepared from wild-type mice but not from MCH1R deficient mice, confirming the specificity and utility of [(35)S]4a as a selective MCH1R radioligand for ex vivo receptor occupancy assays.

CiteXplore: 19361985

DOI: 10.1016/j.bmcl.2009.03.102