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ID: ALA1152909
Journal: Bioorg Med Chem Lett
Title: Low molecular weight non-peptide mimics of omega-conotoxin GVIA.
Authors: Duggan PJ, Lewis RJ, Phei Lok Y, Lumsden NG, Tuck KL, Yang A.
Abstract: We report the synthesis and biological activity of a low molecular weight non-peptidic mimic of the analgesic peptide omega-conotoxin GVIA. The molecular weight of this compound presents a reduction by 193g/mol compared to a previously reported lead. This compound exhibits an EC(50) of 5.8microM and is accessible in only six synthetic steps compared to the original lead (13 steps). We also report several improvements to the original synthetic route.
CiteXplore: 19362476