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ID: ALA1152916
Journal: Bioorg Med Chem Lett
Title: Aryloxypyrazines as highly selective antagonists of Oxytocin.
Authors: Brown A, Ellis D, Pearce D, Ralph M, Sciammetta N.
Abstract: A series of aryloxypyrazines were designed based on structural overlap with previously reported arylpyrazine Oxytocin antagonists. Similarly high levels of Oxytocin antagonism were achievable in this new series. In addition, significant improvements in selectivity over the related vasopressin V(1A) receptor were also possible.
CiteXplore: 19376698