Chloro-oxime derivatives as novel small molecule chaperone amplifiers.

ID: ALA1152919

Journal: Bioorg Med Chem Lett

Title: Chloro-oxime derivatives as novel small molecule chaperone amplifiers.

Authors: Zhou Y, Vu K, Chen Y, Pham J, Brady T, Liu G, Chen J, Nam J, Murali Mohan Reddy PS, Au Q, Yoon IS, Tremblay MH, Yip G, Cher C, Zhang B, Barber JR, Ng SC.

Abstract: Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC(50)<10 microM).

CiteXplore: 19398333

DOI: 10.1016/j.bmcl.2009.03.011

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