Basic Information
ID: ALA1152935
Journal: Bioorg Med Chem
Title: Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
Authors: Shinonaga H, Noguchi T, Ikeda A, Aoki M, Fujimoto N, Kawashima A.
Abstract: WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified radicicol (1) as an active compound, and synthesized several radicicol derivatives. Among them, 6,7-dihydro-10alpha-hydroxy radicicol (31) was found to function as a new potent WNT-5A expression inhibitor with relatively low toxicity and excellent stability.
CiteXplore: 19447629
DOI: 10.1016/j.bmc.2009.04.060
Patent ID: ┄
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