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ID: ALA1153018

Journal: Bioorg Med Chem Lett

Title: Synthesis of pochoxime prodrugs as potent HSP90 inhibitors.

Authors: Wang C, Barluenga S, Koripelly GK, Fontaine JG, Chen R, Yu JC, Shen X, Chabala JC, Heck JV, Rubenstein A, Winssinger N.

Abstract: Pochoximes are potent inhibitors of heat shock protein 90 (HSP90) based on the radicicol pharmacophores. Herein we present a pharmacokinetics and pharmacodynamics evaluation of this compound series as well as a phosphate prodrug strategy to facilitate formulation and improve oral bioavailability.

CiteXplore: 19410458

DOI: 10.1016/j.bmcl.2009.04.030