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ID: ALA1153100
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vivo evaluation of 3-substituted gababutins.
Authors: Blakemore DC, Bryans JS, Carnell P, Chessum NE, Field MJ, Kinsella N, Kinsora JK, Osborne SA, Williams SC.
Abstract: A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.
CiteXplore: 19897364