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ID: ALA1153125

Journal: Bioorg Med Chem Lett

Title: Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.

Authors: Capková K, Hixon MS, Pellett S, Barbieri JT, Johnson EA, Janda KD.

Abstract: A series of benzylidene cyclopentenedione-based inhibitors, acting through covalent modification of the active site of botulinum neurotoxin A light chain metalloprotease, are reported.

CiteXplore: 19914829

DOI: 10.1016/j.bmcl.2009.10.129