Basic Information
ID: ALA1153126
Journal: Bioorg Med Chem Lett
Title: Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection.
Authors: Miller JF, Turner EM, Sherrill RG, Gudmundsson K, Spaltenstein A, Sethna P, Brown KW, Harvey R, Romines KR, Golden P.
Abstract: The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.
CiteXplore: 19914830
DOI: 10.1016/j.bmcl.2009.10.123
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets