Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
Basic Information
ID: ALA1153170
Journal: Bioorg Med Chem Lett
Title: Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
Authors: Venkatesan AM, Dehnhardt CM, Chen Z, Santos ED, Dos Santos O, Bursavich M, Gilbert AM, Ellingboe JW, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, Yu K, Gibbons J, Abraham R, Mansour TS.
Abstract: This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.
CiteXplore: 19954970
DOI: 10.1016/j.bmcl.2009.11.057
Patent ID: ┄