Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

ID: ALA1153183

Journal: Bioorg Med Chem Lett

Title: Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

Authors: Kuduk SD, Di Marco CN, Cofre V, Pitts DR, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger K, Thompson CD, Hartman GD, Bilodeau MT.

Abstract: Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M(1) positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.

CiteXplore: 19962304

DOI: 10.1016/j.bmcl.2009.11.059

Patent ID: ┄