Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

ID: ALA1153216

Journal: Bioorg Med Chem Lett

Title: Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.

Authors: Yang FV, Shipe WD, Bunda JL, Nolt MB, Wisnoski DD, Zhao Z, Barrow JC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Hartman GD, Lindsley CW.

Abstract: An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M(1) positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

CiteXplore: 20004574

DOI: 10.1016/j.bmcl.2009.11.100

Patent ID: ┄