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ID: ALA1153232
Journal: Bioorg Med Chem Lett
Title: Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.
Authors: Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA.
Abstract: Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology.
CiteXplore: 20005705