Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents.
Basic Information
ID: ALA1153280
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents.
Authors: Hu L, Kully ML, Boykin DW, Abood N.
Abstract: A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more active than Vancomycin. The mechanism of action for this class of compounds appears to be different from existing antibiotics. Bis-benzimidazole diamidine compounds have potential for further investigation as a new class of potent anti-MRSA and anti-VRE agents.
CiteXplore: 19208475
DOI: 10.1016/j.bmcl.2009.01.075
Patent ID: ┄