Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.
Basic Information
ID: ALA1153292
Journal: Bioorg Med Chem Lett
Title: Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation.
Authors: Porter J, Payne A, Whitcombe I, de Candole B, Ford D, Garlish R, Hold A, Hutchinson B, Trevitt G, Turner J, Edwards C, Watkins C, Davis J, Stubberfield C.
Abstract: The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.
CiteXplore: 19217289
DOI: 10.1016/j.bmcl.2009.01.071
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets