Document Report Card
Basic Information
ID: ALA1153318
Journal: Bioorg Med Chem Lett
Title: Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
Authors: Emmitte KA, Adjabeng GM, Andrews CW, Alberti JG, Bambal R, Chamberlain SD, Davis-Ward RG, Dickson HD, Hassler DF, Hornberger KR, Jackson JR, Kuntz KW, Lansing TJ, Mook RA, Nailor KE, Pobanz MA, Smith SC, Sung CM, Cheung M.
Abstract: A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.
CiteXplore: 19237286