Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba.
Basic Information
ID: ALA1153329
Journal: Bioorg Med Chem Lett
Title: Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba.
Authors: Qin JC, Zhang YM, Gao JM, Bai MS, Yang SX, Laatsch H, Zhang AL.
Abstract: A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.
CiteXplore: 19246197
DOI: 10.1016/j.bmcl.2009.02.025
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