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ID: ALA1153348
Journal: Bioorg Med Chem Lett
Title: Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.
Authors: Bhat KA, Shah BA, Gupta KK, Pandey A, Bani S, Taneja SC.
Abstract: Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
CiteXplore: 19268586