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ID: ALA1153458
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists.
Authors: Cho K, Ando M, Kobayashi K, Miyazoe H, Tsujino T, Ito S, Suzuki T, Tanaka T, Tokita S, Sato N.
Abstract: A novel series of cyclohexanamine derivatives was designed and synthesized as potent and selective human neuropeptide Y Y1 receptor antagonists. Modification of high-throughput screening hit compound 1 resulted in the identification of compound 3i, which displays potent Y1 activity and good selectivity towards hERG K(+) channel and serotonin transporter.
CiteXplore: 19596193