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ID: ALA1153712

Journal: Bioorg Med Chem Lett

Title: Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules.

Authors: Roy B, Chakraborty A, Ghosh SK, Basak A.

Abstract: A new class of chimeric molecules have been developed. These are based on polyphenols like catechin and epicatechin and monocyclic beta-lactams. The two units are joined via a triazole linker using the 'Click Chemistry' conditions. The compounds showed good to weak antibacterial activity against Escherichia coli as well as moderate inhibition of RNase A.

CiteXplore: 19879760

DOI: 10.1016/j.bmcl.2009.04.084