Document Report Card

ID: ALA1153732

Journal: J Nat Prod

Title: Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

Authors: Zhang H, Rothwangl K, Mesecar AD, Sabahi A, Rong L, Fong HH.

Abstract: Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.

CiteXplore: 19904996

DOI: 10.1021/np900549e