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ID: ALA1153910
Journal: Bioorg Med Chem Lett
Title: Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.
Authors: Kasagami T, Kim IH, Tsai HJ, Nishi K, Hammock BD, Morisseau C.
Abstract: We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.
CiteXplore: 19216074