Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.

ID: ALA1153926

Journal: Bioorg Med Chem Lett

Title: Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.

Authors: Tsuji K, Satoh S, Mitsutake S, Murakami I, Park JJ, Li Q, Chang YT, Chung SK, Igarashi Y.

Abstract: In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta or PPARgamma, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs.

CiteXplore: 19237283

DOI: 10.1016/j.bmcl.2009.02.004

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