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ID: ALA1153989
Journal: Bioorg Med Chem Lett
Title: Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein.
Authors: Tian B, He M, Tang S, Hewlett I, Tan Z, Li J, Jin Y, Yang M.
Abstract: HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC(50) values of 0.21 and 0.17 microM respectively.
CiteXplore: 19297155